this article provides the info necessary for enabling jumbo frames on vswitches and vmkernel interfaces:
http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1007654

there’s also a fantastic document from equallogic that goes step-by-step over setting up the storage networking configuration from scratch. the document is called “TR1049: Configuring VMware vSphere iSCSI…”

installing the equallogic multipathing extension module is detailed in the MEM-User_Guide that accompanies the MEM download. one quick note, the setup.pl –configure option is unnecessary if you’ve already configured a vswitch & vmkernel ports for storage networking.

and here’s a quick few commands:
esxcfg-vswitch -l
list vswitch information

esxcfg-vswitch -p iSCSI2 -N vmnic6 vSwitch2
this unlinks additional vmnics from vmkernel ports (there should only be one vmnic per vmkernel port)

esxcli swiscsi nic add -n vmk1 -d vmhba45
this binds vmkernel ports to the software iSCSI interface

esxcli swiscsi nic list -d vmhba45
this lists vmkernel ports that are already bound to the software iSCSI interface

./setup.pl –server=<ip address/fqdn> –query
ran from vMA, verifies status of equallogic multipathing extension module