it’s necessary to temporarily prevent a compromised exchange account from sending out spam. you could of course disable the mailbox, but then the mailbox would be marked for deletion and would be purged in 30 days. so if you forgot to reconnect the mailbox before the 30 days you’d probably have to restore the mailbox from a backup.

an easier way to accomplish this is to alter the storage limits on the user’s mailbox. change “prohibit send at” to 0KB.

source:
http://social.technet.microsoft.com/Forums/en-US/exchangesvradminlegacy/thread/2bae33f6-4039-462f-b86d-ce873727a1a3

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